Yahoo Sports Staff Updated Tue, October 20, 2026 at 12:10 AM UTC About Our Ads Advertisement Advertisement Advertisement In this story The Washington Commanders and San Francisco 49ers will close out Week 6 on "Monday Night Football," with kickoff set for 8:15 p.m. ET at Levi's Stadium in Santa Clara, California.
Commanders head coach Dan Quinn faces mounting pressure after a 1-3-1 start to the season, as Washington looks to rebound after a perplexing gaffe from quarterback Jayden Daniels in overtime, which resulted in a tie, rather than an opportunity to kick the potential game-winning field goal.
The 49ers enter Monday night as one of three remaining undefeated teams in the league with a 5-0 record, coming off an impressive road win over NFC West rival and defending Super Bowl champion Seattle Seahawks. Quarterback Brock Purdy is playing at an MVP level despite injuries to his receiving corps, with 1,196 passing yards, 13 touchdowns and 2 interceptions through his first five games. He's taken just a single sack all year.
Follow along with Yahoo Sports for live updates, highlights and more as the San Francisco 49ers host the Washington Commanders to close out Week 6 on "Monday Night Football" on ABC and ESPN .
The Washington Commanders made several roster moves ahead of Monday night's showdown with the San Francisco 49ers, including placing starting running back Jacory Croskey-Merritt on injured reserve with a groin injury.
That will force Croskey-Merritt to miss the next four games, with a potential return against the Cincinnati Bengals in Week 11; the Commanders have a Week 7 bye.
Croskey-Merritt currently leads the team with 67 carries this season the year for 239 rushing yards and two scores, adding another 40 yards through the air. He's coming off his best game of the season, averaging 7.5 yards per carry against the New York Giants last week, when he aggravated the groin issue that he first suffered in training camp.
That leaves the Commanders with backs Rachaad White, Austin Ekeler and Jeremy McNichols to carry the load for the time being with Croskey-Merritt out.
Moneyline odds: 49ers -400, Commanders +315
Maybe we're getting coaxed into something that seems too obvious because Daniels ran nine times for 103 yards last week in his return from injuring his elbow in Dallas, but he also had 69 yards on seven carries in one half on that Sunday afternoon. Without a traditional bell-cow running back, Daniels will need to be a significant part of the run game.
The 49ers did well in their only matchup with a mobile quarterback this season, but Malik Willis doesn't have the same big-play ability as Daniels.
The last time San Francisco defensive coordinator Raheem Morris faced Daniels, it was in the quarterback's rookie season, and Morris had no answers then — it was the only other time the Commanders' quarterback ran for over 100 yards. We'll be content with 40 yards' worth of scrambles on Monday night.
Check out the rest of our best bets as the Commanders face the 49ers on "Monday Night Football," including our pick against the spread.
With less than 90 minutes until the Commanders and 49ers kick off, each team has announced its Week 6 inactives. Here's a look:
Source: Sports
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